CRS Scientist Spotlight on Huma Asif

Huma Asif, PhD, is a Research Assistant Professor in the Kim Lab. Her research focuses on identifying race-specific biomarkers for Black and white women with endometrial tumors using data from The Cancer Genome Atlas.

What brought you to join the CRS community and what is your current position? 

I joined the CRS community, driven by a passion for advancing cancer research and addressing health disparities through innovative, data-driven multi-omics approaches. I am currently a Research Assistant Professor in Dr. Julie Kim's lab and am thrilled to be part of this amazing community. 

Could you describe your research?

My research focuses on identifying race-specific biomarkers for Black and white women with endometrial tumors using data from The Cancer Genome Atlas (TCGA). By integrating genomic, epigenomic, and transcriptomic data, we produced the first report highlighting race-specific methylation differences. Using advanced machine learning methods, we identified 38 epigenetic signature genes (ESGs) in these tumors, incorporating genetic ancestry estimation. By combining insights from ancestry and race, we aim to identify patient groups that will benefit from these biomarkers for targeted treatments. Additionally, I am exploring how epigenetic changes influence the biological age of tumors in Black and White women using epigenetic clocks. 

What aspects of CRS do you find most valuable or look forward to engaging in? 

The CRS fosters meaningful connections between students, faculty, and the broader reproductive science community through weekly seminars, invited speaker sessions, and career networking events. I look forward to engaging in these networking opportunities, developing new collaborations, and expanding my knowledge within the field of reproductive science. 

What has been the most valuable aspect to your training as a reproductive scientist?

The most valuable aspect of my training as a reproductive scientist has been developing data-driven hypotheses using public databases and learning high-throughput next-generation sequencing techniques. In my current role, I have expanded my skillset through collaborations with fellow students in the lab, and these experiences have fueled my enthusiasm to take on new challenges. 

What would you recommend to junior scientists in order for them to succeed in their scientific careers? ​

I would recommend young scientists work hard, stay consistent, and remain open to learning new skills. Sharing knowledge with others and not fearing failure or rejection are key to growth. Set clear goals and seek guidance from mentors, as their advice is invaluable for overcoming challenges and advancing your career. 

What do you think will be the next big contribution in the reproductive biology field? 

I believe the next big contribution in reproductive biology will be a deeper understanding of the endometrium's role in aging and fertility. While earlier studies focused on ovarian aging, recent research highlights how both the biological and chronological age of the endometrium can influence pregnancy success and fertility. I am particularly interested in the impact of endometrial aging on conception and pregnancy success, especially in women with endometriosis. I find this area of research promising and look forward to seeing its potential effects on reproductive health outcomes. 

What hobbies do you have outside of the lab?  

My hobbies outside the lab include cooking, traveling, playing with my bunny Bia, and having FaceTime virtual parties with my family and friends, most of whom live abroad.