CRS Scientist Spotlight on Janavi Thyagraj

Janavi Thyagraj is a second year MS-RSM student conducting research in the lab of Dr. Monica Laronda. Her project focuses on understanding adrenal insufficiency and its impact on steroidogenesis and fertility.

Mentor: Monica Laronda, PhD

Thesis Title: "The First Steps in Developing an In Vitro Assay to Predict Adrenal Gland Function Using Human-Induced Pluripotent Stem Cells."

What brought you to join the CRS community and what is your current position?

Could you describe your research? 

My project focuses on understanding adrenal insufficiency and its impact on steroidogenesis and fertility. I am working on developing a prototype of an in vitro diagnostic tool using stem cell-derived adrenal cortex-like cells for early detection of adrenal insufficiency. To give some more context, the adrenal gland and the gonads are involved in steroidogenesis. In certain cases, mutation in steroidogeneic genes can impair function of both organs. Impaired steroid hormone synthesis can have detrimental effects. Unfortunately, it is difficult to detect sex steroid deficiency before puberty. I hope to model this condition, study it’s progression and develop a preliminary predictive and diagnostic tool.  

What aspect(s) of CRS do you find most valuable?  

Finding community among my cohort and lab continues to be one of the most valuable aspects of CRS for me. The people I am surrounded by are a wealth of knowledge, empathy and humour. During my time as a student, I have met some of the most amazing professors, scientists and clinicians. They are very enthusiastic to talk and share details about their research and career. I highly appreciate their interest and patience while teaching complex topics. I enjoy learning about clinical applications and the implications of our field. It’s amazing to know you can access a wide range of literature and connect with the respective scientists through CRS.  

What has been the most valuable aspect of your training as a reproductive scientist? 

As a research trainee in the CRS and the Laronda lab, I have been exposed to various laboratory procedures and projects. Since my lab is closely associated with Lurie Children’s Hospital, I get to participate in novel and exciting translational research.  Through the courses I have been able to interact with clinicians who have talked at great length about how upcoming technologies impact patients and emphasized the importance of conducting research in the reproductive science sector.  

What is one piece of advice you would give to young scientists starting their journey in science?  

From my experience, I have learned that robust research takes time so it is acceptable to progress steadily. I try my best to set a weekly agenda to pace myself and remain consistent. When I need motivation, I try to think about the larger context and application of my research. It’s a cliché saying but I would encourage upcoming RSM students to keep an open mind and learn what each laboratory has to offer. Something that I have heard is that the people you work with are just are important as your project.  

What do you think will be the next big contribution in the reproductive biology field?  

From what I gather in lab, we are working towards developing more efficient techniques for in vitro maturation of ovarian follicles and fertility restoration techniques. We are also seeing an emergence in research focusing on understanding the interplay of glucose metabolism, diabetes mellitus and Polycystic Ovarian Syndrome (PCOS). Sex education and awareness continues to become better and more inclusive which is exciting. I hope we can build global consortiums for reprodutive science to foster collaborations across nations and share innovative technologies worldwide. In class we have been learning about policy making and advocacy I’m cautiously optimistic about reforms in reproductive rights. Personally, I hope research in reproductive science comes to the forefront in my home country, India! 

What hobbies do you have outside of the lab?  

Walking around the city when the sun is my new favorite activity. When I am home, I tend to cook interesting recipes that I see on social media aside from the comfort food that reminds me of home. I strongly believe that a steamy hot bowl of dal rice can solve everything! I also find a lot of comfort in reading fiction. It’s the perfect escapism after a long day in the lab. Sometimes, I spend my time watching Indian classical dance content.