Alumni Spotlight on Yi Luan, PhD

Yi Luan, PhD, is an MS-RSM graduate, Class of 2018. She completed the thesis track under the mentorship of Dr. So-Youn Kim in Dr. Teresa Woodruff's lab. She is currently a senior scientist at AstraZeneca.

Thesis mentor: So-Youn Kim, PhD 
Thesis title: "Underlying Mechanism Of Ovarian Reserve Preservation From Gonadotoxicity"

What is your connection to the CRS community (mentor and position) and what is your current position? 

During my time as part of the inaugural MS-RSM class, I successfully completed my master's training in Dr. Teresa Woodruff's lab, under the mentorship of Dr. So-Youn Kim. Building upon this experience, I went on to contribute as a Research Assistant for one year in Dr. Sarki Abdulkadir's lab. Subsequently, I pursued my PhD at the University of Nebraska Medical Center, under the guidance of Dr. So-Youn Kim, while continuing my research on the mechanism of chemotherapy-induced ovarian dysfunction. Currently, I hold the position of a senior scientist at AstraZeneca in the early oncology department.  

Could you describe your current research/studies? 

In my current research, my primary focus revolves around identifying and validating new potential targets for the development of bispecific antibodies. These antibodies hold promise for treating a wide range of cancers, such as pediatric sarcomas, non-small cell lung cancer (NSCLC), renal cell carcinoma, etc. 

What aspect(s) of CRS did you find most valuable?  

CRS has created a remarkable community that I genuinely cherish, akin to a large and supportive family. This community consists of esteemed professionals from various disciplines within and beyond the realm of reproductive science and medicine, encompassing individuals at different stages of their academic and career paths. CRS offers numerous interactive platforms to actively involve its trainees, pushing them to continually improve as scientists. The opportunity to connect, network, and engage with such a diverse group of scientists and clinicians has been instrumental in my growth as a student and reproductive scientist, enabling me to thrive in this field. 

What has been the most valuable aspect to your training as a reproductive scientist in CRS? 

CRS served as the pivotal moment that solidified my decision to pursue a career as a scientist. One of the most invaluable aspects I acquired during my training within CRS was the enduring mentorship and lasting friendships I established. The unwavering support I received from these individuals s throughout my training was truly priceless. Additionally, CRS provided me with opportunities to showcase my research at various scientific meetings and conferences, allowing me to refine my presentation and communication skills. Moreover, engaging with senior scientists during these events broadened my perspective, encouraging me to think on a larger scale and develop a more comprehensive scientific vision. These invaluable opportunities and interactions have profoundly influenced and guided my path as a scientist. 

What would you recommend to junior scientists in order for them succeed in their scientific careers?​  

I personally still regard myself as a ‘junior scientist’, acknowledging the considerable presence of seasoned scientists who have dedicated their entire lives to the pursuit of science. If I were to offer advice to my younger classmates, I would encourage them to remain authentic to themselves. It is crucial to recognize that you, as an individual, possess the most profound understanding of your own talents, potential, and passion. By embracing this self-awareness, you can identify the areas that truly captivate your interest and where your capabilities excel. By pursuing these genuine passions and leveraging your strengths, you can embark on a fulfilling scientific journey.  

What do you think will be the next big contribution in the reproductive biology field?  

I believe there is a significant need for further research in examining the side effects of current cancer immunotherapy in patients, particularly in the context of pediatric patients. Additionally, exploring potential strategies to safeguard fertility in the face of advanced cancer therapies warrants more attention and investigation. 

Do you have any notable stories from your time in CRS? 

During my time in CRS, I have vivid memories of our engaging Oncofertility Science Academy Program (OSA) held annually during the summer. Our laboratory curated a diverse range of scientific sessions specifically designed for middle and high school students. As part of the MS-RSM, we organized a session showcasing the ovulation process during the female menstrual cycle using an "ovulation clock”. Additionally, our lab facilitated practical laboratory sessions to actively involve the high school students in hands-on experiences. 

Reflecting on those experiences, I often wished that I had similar opportunities as a child to witness firsthand what "science" truly entails. It is my sincere hope that through programs like OSA, some of these bright young individuals may find their passion and pursue a career in reproductive science in the future. Witnessing their journey would be immensely fulfilling for me.